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Yale Scientists Develop Precision Medicine Approach to Metabolic Therapy for Breast Cancer

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Between 2011 and 2030, the incidence of breast cancer is expected to rise by more than 50%.

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This prediction is partly due to increased obesity rates, which hasten

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the occurrence and progression of breast cancer in postmenopausal women.

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Yale researchers investigated the SGLT2 inhibitor dapagliflozin as an alternative to metformin

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using a novel class of diabetic medicine known as SGLT2 inhibitors.

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The study used animal models to see how receptive breast cancers were to dapagliflozin in addition to chemotherapy.

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The combined therapy had no effect on models of breast cancer caused by mutations

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downstream of the insulin pathway or in pathways with other driver mutations.